The Liverpool School of Pharmacy at Liverpool John Moores University is the second oldest School of Pharmacy in the United Kingdom (founded in 1849), the University itself has over 24, 000 students and is one of the largest Universities in the UK.
The QSAR and Modelling Group based within the School of Pharmacy and Biomolecular Sciences has undertaken research into in silico alternatives for over 40 years and has broad expertise in the development of in silico models for biological activity, and toxicity in particular. The researchers investigate the relationships between biological activity and the physico-chemical properties of compounds. This area includes the development of quantitative structureactivity relationships (QSARs) to predict toxicological and pharmacological as well as physico-chemical parameters.
The researchers in the QSAR and Modelling Group are dedicated to application of these methods to industrial settings and have experience of serving on various working groups and national committees including: OECD, ECB, ECVAM, US EPA, Cefic etc. They have expertise in training non-experts and experts alike in the development and application of in silico techniques for toxicity prediction, including ECB training courses, training courses on EU projects and bespoke training programmes for industry. The Group has been involved in a number of EU projects including OSIRIS, CAESAR, ReProTect, InSilicoTox, IMAGETOX, and the OECD (Q)SAR Application Toolbox.
LJMU coordinates the COSMOS project and is responsible for the day-to-day management. Other key tasks include toxicological data retrieval, curation, quality assessment and databasing as well as the development of innovative computational approaches to predict toxicity. LJMU is also leading the dissemination of results and integration of COSMOS with other projects.