All cosmetic ingredients must be demonstrated to be safe for application to humans. Currently there are two distinct channels in the safety evaluation of cosmetic ingredients:
There is a requirement to assess the effects of repeated doses of cosmetic ingredients. However, the 7th Amendment to the Cosmetics Directive and the new Cosmetic Products EU Regulation has banned the marketing of cosmetics tested for this endpoint in animals.
In general, the Cosmetics Directive puts an end to animal testing by banning:
Animal tests should be replaced by alternative safety assessment methods.
However, currently no validated alternatives exist for the prediction of repeated dose toxicity. In addition, there is an increasing concern that animal testing and the existing alternatives are not adequately protective of human health. Therefore, as part of the Seurat-1 cluster of alternatives projects, COSMOS has developed a suite of computational prediction models and approaches to assist in the assessment of the safety of cosmetic ingredients.