COSMOS - a European Union project developing methods for determining the safety of cosmetic ingredients for humans, without the use of animals, using computational models.

SEURAT-1 logo.COSMOS was one of seven projects forming the SEURAT-1 cluster, SEURAT being a European research initiative with the long-term goal of achieving "Safety Evaluation Ultimately Replacing Animal Testing".

COSMOS was a unique collaboration addressing the safety assessment needs of the cosmetics industry, without the use of animals. The main aim of COSMOS was to develop freely available tools and workflows to predict the safety to humans following the use of cosmetic ingredients.

The project ran from January 2011 - December 2015.

Major results and links to the legacy tools are availabe from this website.


COSMOS Symposium

COSMOS Symposium on Computational Tools for Safety Assessment Focussing on Cosmetics Ingredients

The Symposium was held on 9 September 2015 at Liverpool John Moores University, UK. The one day workshop event presented an overview of the outcome and legacy of the EU COSMOS Project.

The presentations were webcasted live to an international audience as well as being recorded.

The recorded presentations are available here.

For more information see also the Symposium homepage.


The COSMOS Workflows are freely available to use!

They are freely accessible to execute in a web browser in the COSMOS KNIME WebPortal.

Free registration, model description and user guidance are available through COSMOS Space.
Login to the COSMOS KNIME WebPortal with COSMOS Space credentials.

Web tutorials for the COSMOS KNIME WebPortal workflows are available here.


Models include

  • Biokinetics:

    • Physiologically-Based Kinetic (PBK) models to simulate concentration-time profiles and internal dose metrics for dermal or oral scenarios

    • Extrapolation of in vitro intracellular concentrations with the Virtual Cell Based Assay

    • Human bioaccumulation factor (hBCF)

    • Gastrointestinal absorption

    • Skin permeability

  • Receptor Binding and Structural Alerts:

    • Prediction of potential binding to nuclear receptors related to steatosis

Click for a PDF of the COSMOS Workflows leaflet.

COSMOS KNIME Workflow leaflet for download.




COSMOS Database v1.0 is publicly available since December 2013

It is freely available here. After free registration with your email address you can access:

  • More than 80,000 chemical records with more than 40,000 unique structures

    Searchable by

    • Name, CAS number, IDs.
      One substances or a list of chemicals.

    • Chemical structure – exact, substructure and similarity search.
      Sketch your own query or enter SMILES.

  • More than 12,000 toxicity studies across 27 endpoints for more than 1,600 compounds

    • US FDA PAFA dataset generously donated by the US FDA Office for Food Additives Safety (OFAS) and oRepeatToxDB compiled by the COSMOS Consortium.

    • Endpoints including both repeat dose toxicity studies and genetic toxicity data.

    • Toxicity data searchable by endpoints, test system, route of exposure, sites or other details.

A short summary of the content of the COSMOS Database version released can be found here.

COSMOS DB homepage.

Click here for a link to the COSMOS Database and see also the COSMOS DB page.


The COSMOS has developed and evaluated the following computational tools and approaches:

The five year project brought together expertise from 15 partners from academia, industry, SMEs, and regulatory agencies from across Europe as well as the USA. It was coordinated by Liverpool John Moores University, England.


COSMOS was funded by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 266835 and the European Cosmetics Association Cosmetics Europe


This is European Comission Project. Seventh Framework Programme. Cosmetics Europe, The Personal Care Association. COLIPA, The European trade association for the cosmetic, toiletry and perfumery industry.