Although several databases for chronic toxicity data are available, no single repository of chronic toxicity data exists that is truly open and transparent and includes all aspects of the data such as protocol details.
Therefore, the COSMOS project is building a new database that will deliver a single, comprehensive and reliable resource for repeated dose toxicity data. Moreover, the database will include dermal absorption and metabolism data. It will be linked to high quality and validated chemical structure and chemoinformatics tools to facilitate modelling.
The COSMOS database is being created as a relational database, linking chemical structure to repeated dose toxicity data. Bespoke data curation and quality assessment strategies are used for quality control, both of chemical structures and toxicity data.
Results for repeated dose toxicity tests will be recorded in detail; the database will be sufficiently flexible to enable recording of additional toxicity results as they become available.
The COSMOS database and the data within it will be made freely available, thus providing an invaluable resource for the modelling efforts as well as a platform to encourage data sharing and donation. The data repositories will be completely open i.e. will not require specialist software to be used for search and retrieval.
Data donations from industry are welcome to complement the available toxicity data, different levels of confidentiality can be accommodated, ranging from access for the donor only, the SEURAT-1 consortium or data being publicly available.
An inventory of cosmetics ingredients has been compiled from the European Commission's Cosmetics Ingredients (CosIng) database and the list compiled by the US Personal Care Products Council (PCPC), applying chemoinformatics techniques. The COSMOS Cosmetics Inventory currently includes a set of over 5500 unique chemical structures.
The COSMOS Cosmetics Inventory allows, for the first time, quality assured chemical structures to be associated with cosmetics ingredients. The COSMOS Cosmetics Inventory will be incorporated into the COMSOS database and will be searchable flexibly. It will thus assist with the understanding of chemical space of cosmetic materials and enable chemical grouping and modelling.