In Vitro - In Vivo Extrapolations

COSMOS Webinar on Automated IVIVE In Silico Tools

The COSMOS webinar "Automated in silico tools for in vitro to in vivo extrapolation" was held on 13 April 2015, hosted by the American Society for Cellular and Computational Toxicology (ASCCT).

A recording of the webinar is available here.


  • Establishment of kinetic and physiologically-based pharmacokinetic (PBPK) models, in vitro, in silico and other relevant data to predict target organ concentrations and long term toxicity to humans.

The aim is to predict the dose of a cosmetic ingredient at the target organ level from in vitro (and other) information, allowing for corrections due to experimental conditions and metabolism and to upscale the in silico and in vitro methods at organ and body level to develop complete absorption, distribution, metabolism and excretion (ADME) models for decision making and risk assessment of cosmetic ingredients. In addition, no observable (adverse) effect concentration (NO(A)EC) as a measure of toxicity will be derived from in vitro repeated dose systems and PBPK modelling should allow prediction of corresponding in vivo concentration-dose. Finally, the application of these models by predicting internal concentrations will support the application of the TTC concept.

In Vitro - In Vivo Extrapolations

The aim is to formulate an integrated modelling approach that will incorporate toxicological data from the corresponding levels:

Integrated modelling approach.


This is European Comission Project. Seventh Framework Programme. Cosmetics Europe, The Personal Care Association. COLIPA, The European trade association for the cosmetic, toiletry and perfumery industry.